When it comes to reducing fine lines and wrinkles, Botox has long been the go-to name, but it’s not the only option available. Xeomin is a newer injectable treatment that offers similar results with a few important differences. Both are popular neuromodulators derived from botulinum toxin type A and are FDA-approved for cosmetic and medical uses. However, there are key distinctions between the two that can impact which one is better suited for your individual needs that we at Open Door Med Spa would like to share today.

Botox VS Xeomin: Which Should I Choose?

1) Formulation and Purity. One of the most significant differences between Xeomin and Botox lies in their formulation. Botox contains accessory proteins along with the botulinum toxin, which help stabilize the molecule. In contrast, Xeomin is a “naked” neurotoxin, meaning it contains only the active botulinum toxin without any added proteins. This purity can reduce the risk of the body developing antibodies against the treatment, which could make it less effective over time.
Because of its purified structure, Xeomin is often considered a better choice for patients who have developed resistance to Botox or who are undergoing long-term treatments.
2) Onset and Duration. The onset of results is slightly different between the two. Botox generally starts to show visible effects within 3 to 5 days, with full results in about a week. Xeomin, on the other hand, may take a little longer to show full results—typically 5 to 7 days.
In terms of longevity, both products offer results that last around 3 to 4 months, depending on the area treated, dosage, and individual patient factors. Some people report that Xeomin wears off slightly sooner, while others find it lasts just as long as Botox.
3) Storage and Handling. Another difference is how the two products are stored. Botox requires refrigeration before use, while Xeomin is stable at room temperature. This difference in storage doesn’t affect performance but can offer added convenience for some providers and patients.
4) FDA Approvals and Uses. Both Xeomin and Botox are FDA-approved for treating glabellar lines (the frown lines between the eyebrows). Botox has additional FDA approvals for crow’s feet and forehead lines, while Xeomin is often used off-label for those same areas. Medically, both are used to treat conditions like chronic migraines, excessive sweating, and muscle spasms.
5) Cost Considerations. Price can be a deciding factor for many patients. In general, the cost per unit of Xeomin is slightly lower than that of Botox. However, since the number of units needed to achieve the same effect may differ, the overall cost often ends up being similar. Consulting with an experienced provider is the best way to determine the most cost-effective option for you.

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Xeomin and Botox are both effective, well-studied treatments for reducing the appearance of wrinkles and managing certain medical conditions. While they work in similar ways, their differences in formulation, onset time, and protein composition may influence which one is right for you. A qualified injector can help you make the best choice based on your goals, medical history, and previous experience with neurotoxin treatments. Reach out to Open Door Med Spa to schedule your appointment!